You described my life journey to a tee, and it was only through work because of the referral of my cause to the University of Calgary, did I finally get diagnosed with Pernicious Anemia and Hasimoto's Thyroiditis. You described accurately my journey, and the loss of feeling i have in both my hands and legs. I also experience significant brain fog, and often feel i did not wakeup until i was 38 years old. I was walking around in a fog for most of my life. I also have other auto immune diseases as well, like psoriasis another auto immune condition. I find i have a slow metabolic rate, experience constant constipation, my heart rate is in the 40's, my bowel is irregular. I have recently adopted a ketogenic diet, that has helped a lot, and well as a commitment to 1 hour of elevated exercise a day, to keep my metabolism running a little faster. I take regular B12 injections about two weeks apart.
Holy Sh!t - I think this doc just helped me solve my medical mystery! I have every symptom listed but two, including worsening small fiber neuropathy and severe pain. I’ve mentioned to countless doctors the fact that my mother was hospitalized for PA in 1950s, but every single one has blown it off. Unreal. I am now almost certain that my problems are caused by PA. THANK YOU for this video!!!
So scary, rrmother. There's a medical research paper you can look up too, it's called The Many Faces of Cobalamin Deficiency. Extensive list, very informative
Why are "regular doctors" so ignorant of pernicious anemia? General practitioners do not seem to know about intrinsic factor, about the test for intrinsic factor. General practitioners do not seem to know best practice for treating a person with pernicious anemia. I had a pharmacist tell me, with absolute confidence, that sublingual B12 is no more effective in absorption than taking a swallowed pill form of B12. Doctors still test only for B12 levels and with that test assume no pernicious anemia. My doctor has never discussed how I should also be taking methylated B9 and/or SAM-E. My doctor has never tested for parietal cell factor antibodies or homocysteine. General practitioners seem to treat pernicious anemia as if it was a minor, passing issue. Why is this?
Agree. Its an Ego check for all in the medical field... Discovering that my mothers HRT has likey caused my PCOS, excessive bleeding + other conditions to be exacerbated. For a long time, I thought it was all about iron. The things we wish we new 10, 15, 20 yrs ago! Regards and love to all 🩵
Cus they are stupid……they know little about a lot of stuff. Specialists know a lot about 1 condition. A real comprehensive blood panel from anaemia/pernicious anaemia is expensive and very detained :) They misdiagnose you for MS or something serious as they are so stupid not to run blood tests to save your life. Pernicious anaemia is serious.
1) They dont care 2) They themselves are just fine and get paid either way while enjoying their elevated position within society 3) They already know everything because they made it through school and into a career 3) They are uncurious and have no urge to discover and solve problems 4) They don't have time etc etc... 5) See number 1
Because of a dirty big secret of how ALL medications are poison and their only method of action is to exhaust your vitamin and mineral reserves to stop the healing repair process which we are led to believe is the illness which it isn't!!
Thank you so much for this! At times, it was a little dense and difficult to work through, especially when you used abbreviations that hadn’t been priorly explained, but most of it I got. I have AIG and am receiving monthly B12 injections (in the first 4 weeks on a weekly basis. Have improved but still quite sick, not sure I am properly utilizing the B12 yet. If you are interested in doing research, I am one of nine siblings, many of whom suffer from PA and related symptoms (as yet I am the only one with a formal diagnosis of autoimmune atrophic gastritis type A), whereby my mother and my maternal grandfather were also treated for PA with monthly injections for all of the time that I knew them until they died, we would be more than happy to accommodate that research in any way we can. Please let me know. Again, thank you so much for your video!
Moja hipoteza anemii złośliwej u mnie : w dzieciństwie, ok. 6 roku życia, w moim domu nastąpiło prawdopodobnie zakażenie helicobacter pylori , u mnie objawiające się totalnymi, ogromnymi migrenami, z silnymi bólami głowy, nudnością i wymiotami trwającymi wiele godzin każdorazowo, po niektórych pokarmach, najczęściej tłustych. Utrzymywało się to wiele lat. U brata i ojca tych objawów nie pamiętam, byłam dzieckiem. Po upływie czasu, u brata zdiagnozowano anemię złośliwą, Addisona Biermera . Otrzymał leczenie wit. B12 1000 x dzień i. m., ale po miesiącu zaprzestał iniekcji. Wyjechał z domu, tylko raz, w wieku 30 lat dał znać o pomoc, leżał w szpitalu psychiatrycznym z objawami schizofrenii - a dotąd był zdrowy psychicznie., pomogłam mu wtedy , po czym zniknął i znów wyjechał. Nie brał witaminy B12. Ja sama miałam anemię z braku żelaza, MCV było w normie, ale w obrazie krwinki czerwone bardzo zróżnicowane wielkościowo, liczne owalocyty , mikrocyty. Suplementowałam żelazo często, aż do menopauzy. Miałam też problem z zajściem w ciążę, poronienia. W końcu jedna ciąża z sukcesem, córka urodziła się zdrowa, jest teraz lekarką. 3 krotnie wykonałam gastroskopię, w wieku 25, 42 i 60 lat. Opis zawsze - to zapalenie zanikowe żołądka. Zalecenia - suplementowanie wit B complex ( bagatelizowane przeze mnie) oraz kontrolne gastroskopie w celu zapobiegania rakowi żołądka ( dlatego 3 razy wykonałam) Po 60 roku życia rozwinęły się u mnie objawy polineuropatii, w stopach symetrycznie powstał w części śródstopia niedowład, wynikający z ucisku na nerw w związku z płaskostopiem poprzecznym. Były nieprzyjemne doznania mrowienia, zaburzenie odczuwania temperatury, określane jako parestezje, a przez nie zaburzenie zasypiania , stany depresyjne, niechęć do działania. Poziom wit B12 - 230 pg/ml, homocysteina 43,2 mol/l , p/ciała przeciwko komórkom okładzinowym 67,7. Lekarz rodzinny z wielkim trudem dał się namówić na wypisanie recepty na zastrzyki z wit. B12 , początkowo 100, po konsultacji hematologa 1000. Po leczeniu witaminą B12 i. m. 1000 / co2 dni - 10 amp a póżniej 1 amp 1 raz / tydzień 1000 - kontrola wit B12 po 2 miesiącach -890 pg/ml homocysteina - 9mol/l , uległy poprawie wyniki lipidogramu, HDL wzrost, LDL spadek o ok. 30 % Ustąpiły parestezje, pozostał niedowład w części śródstopia, wrażliwość na ucisk części ciała, ale już nie tak nieprzyjemny, mniej nasilony. Mój neurolog początkowo był bardzo sceptyczny co do mojej sugestii braku wit B12, niby później ją uznał, gdy zobaczył wynik ENG, które wykazało polineuropatię, ale nadal chce wykluczyć inne przyczyny w szpitalu, mam mieć badanie płynu mózgowo-rdzeniowego i całą diagnostykę. Piszę to wszystko tak szczegółowo, bo chcę przybliżyć od strony pacjenta tę sytuację, wiedząc, że to choroba rzadka i przez społeczeństwo a często samych lekarzy nieznana. Bardzo dziękuję za wspaniały wykład, wszystko to u mnie się potwierdziło, po raz pierwszy aż tak dokładnie mi ktoś to wytłumaczył . Wielkie dzięki z Polski!
And it’s important to note that the intrinsic factor test is only 40-60 percent accurate so as this amazing doctor has said you need to put all, the other factor s together . I had a level of 180 then 130 4 yrs later, before I was treated .My folate was 2 . All my M tests were high .. and I also have every symptom listed. I truly believe if I hadn’t started on daily b12 shots 18 months ago I would have died. Thank you so much to this amazing doctor who if you missed it very lightly also touched on the mylene sheath being affected by b12 deficiency decline in the sheath is also major factor in MS..
Thank you so much. Is it possible for you to provide a link to the physiology diagram in the description at 11mins...? Fascinating learning this for the first time. My Gps always thought I had a mild iron deficiency. I was deteriorating also due to a Candida overgrowth, robbing nutrients. Sublingal B12 has improved my symptoms dramatically within 24hrs. Cheers! Keep up the good work and sincere thanks for putting this up for us on RUclips 😊 Molly
My son doesn't have IF, so he can't absorb B12. He has been diagnosed with pernicious anemia. We get him.B12 shots regularly methy and sometimes hydroxyl. Should he also be supplementing with B9, folate, or folic acid? I hear so much debate on all thing pernicious anemia. It gets confusing. It took years before finally getting a correct diagnosis. At first, they thought he had MS. This has been a long journey he's on, and it has taken its tole on him physically. He still struggles with his health quite a bit, but he is a lot better than he was 5 years ago. Can he absorb B9 without intrinsic factor? And is there a way to supplement with intrinsic factor 🤷♀️
I'm wondering that as well. In my case, I've got high MCV confirmed by peripheral blood smear, positive IFA, high serum B12 (I've always taken an oral B-complex), and normal B9, MMA and homocysteine. Yet, I've experienced all the severe PA symptoms (neurologic included) and they're resolving very slowly with high dose injections of methylcobalamin. I've injected daily for 2 months now and am still making tiny improvements.
Intrinsic factor antibodies interfere with the B12 serum levels. A normal/high B12 can be seen with the IF antibodies. So you have to either test for IF antibodies or look at other areas of the blood which might indicate a B12 deficiency. I have elevated folate which apparently indicates a B12 deficiency (as you need B12 to process folate).
Yes. PA is closely linked to Hashimotos, as is a B12 deficiency. Some people believe that it’s the B12 deficiency that causes Hashimotos which is interesting as I showed symptoms of anemia and then low stomach acid before I was diagnosed with Hashimotos. I’m trying to get my doctor to test me for PA at the moment and have been supplementing with a high b complex methylated supplement which has made me feel semi normal. Trying to get my gp to do anything is hard work so I might have to do a private test 😢
You described my life journey to a tee, and it was only through work because of the referral of my cause to the University of Calgary, did I finally get diagnosed with Pernicious Anemia and Hasimoto's Thyroiditis. You described accurately my journey, and the loss of feeling i have in both my hands and legs. I also experience significant brain fog, and often feel i did not wakeup until i was 38 years old. I was walking around in a fog for most of my life. I also have other auto immune diseases as well, like psoriasis another auto immune condition. I find i have a slow metabolic rate, experience constant constipation, my heart rate is in the 40's, my bowel is irregular. I have recently adopted a ketogenic diet, that has helped a lot, and well as a commitment to 1 hour of elevated exercise a day, to keep my metabolism running a little faster. I take regular B12 injections about two weeks apart.
Holy Sh!t - I think this doc just helped me solve my medical mystery! I have every symptom listed but two, including worsening small fiber neuropathy and severe pain. I’ve mentioned to countless doctors the fact that my mother was hospitalized for PA in 1950s, but every single one has blown it off. Unreal. I am now almost certain that my problems are caused by PA. THANK YOU for this video!!!
So scary, rrmother. There's a medical research paper you can look up too, it's called The Many Faces of Cobalamin Deficiency. Extensive list, very informative
@ Thanks for the info on the research paper! Will def be looking that up. THANK YOU!!
@@rrmother3748 you are so welcome! I'm sure you'll find it fascinating. I got others if you finish and want more.
Why are "regular doctors" so ignorant of pernicious anemia? General practitioners do not seem to know about intrinsic factor, about the test for intrinsic factor. General practitioners do not seem to know best practice for treating a person with pernicious anemia. I had a pharmacist tell me, with absolute confidence, that sublingual B12 is no more effective in absorption than taking a swallowed pill form of B12. Doctors still test only for B12 levels and with that test assume no pernicious anemia. My doctor has never discussed how I should also be taking methylated B9 and/or SAM-E. My doctor has never tested for parietal cell factor antibodies or homocysteine. General practitioners seem to treat pernicious anemia as if it was a minor, passing issue. Why is this?
Agree. Its an Ego check for all in the medical field...
Discovering that my mothers HRT has likey caused my PCOS, excessive bleeding + other conditions to be exacerbated. For a long time, I thought it was all about iron.
The things we wish we new 10, 15, 20 yrs ago!
Regards and love to all 🩵
Cus they are stupid……they know little about a lot of stuff. Specialists know a lot about 1 condition. A real comprehensive blood panel from anaemia/pernicious anaemia is expensive and very detained :) They misdiagnose you for MS or something serious as they are so stupid not to run blood tests to save your life. Pernicious anaemia is serious.
1) They dont care 2) They themselves are just fine and get paid either way while enjoying their elevated position within society 3) They already know everything because they made it through school and into a career 3) They are uncurious and have no urge to discover and solve problems 4) They don't have time etc etc... 5) See number 1
Because of a dirty big secret of how ALL medications are poison and their only method of action is to exhaust your vitamin and mineral reserves to stop the healing repair process which we are led to believe is the illness which it isn't!!
Thank-you for the lesson in biochemistry. My doctor would never understand this. But I do.
Thank you so much for this! At times, it was a little dense and difficult to work through, especially when you used abbreviations that hadn’t been priorly explained, but most of it I got. I have AIG and am receiving monthly B12 injections (in the first 4 weeks on a weekly basis. Have improved but still quite sick, not sure I am properly utilizing the B12 yet. If you are interested in doing research, I am one of nine siblings, many of whom suffer from PA and related symptoms (as yet I am the only one with a formal diagnosis of autoimmune atrophic gastritis type A), whereby my mother and my maternal grandfather were also treated for PA with monthly injections for all of the time that I knew them until they died, we would be more than happy to accommodate that research in any way we can. Please let me know. Again, thank you so much for your video!
P.S. I forgot to say that one sister who had pernicious anemia subsequently died of a neuroendocrine tumour…
Moja hipoteza anemii złośliwej u mnie : w dzieciństwie, ok. 6 roku życia, w moim domu nastąpiło prawdopodobnie zakażenie helicobacter pylori , u mnie objawiające się totalnymi, ogromnymi migrenami, z silnymi bólami głowy, nudnością i wymiotami trwającymi wiele godzin każdorazowo, po niektórych pokarmach, najczęściej tłustych.
Utrzymywało się to wiele lat. U brata i ojca tych objawów nie pamiętam, byłam dzieckiem. Po upływie czasu, u brata zdiagnozowano anemię złośliwą, Addisona Biermera . Otrzymał leczenie wit. B12 1000 x dzień i. m., ale po miesiącu zaprzestał iniekcji. Wyjechał z domu, tylko raz, w wieku 30 lat dał znać o pomoc, leżał w szpitalu psychiatrycznym z objawami schizofrenii - a dotąd był zdrowy psychicznie., pomogłam mu wtedy , po czym zniknął i znów wyjechał. Nie brał witaminy B12.
Ja sama miałam anemię z braku żelaza, MCV było w normie, ale w obrazie krwinki czerwone bardzo zróżnicowane wielkościowo, liczne owalocyty , mikrocyty. Suplementowałam żelazo często, aż do menopauzy.
Miałam też problem z zajściem w ciążę, poronienia. W końcu jedna ciąża z sukcesem, córka urodziła się zdrowa, jest teraz lekarką.
3 krotnie wykonałam gastroskopię, w wieku 25, 42 i 60 lat. Opis zawsze - to zapalenie zanikowe żołądka. Zalecenia - suplementowanie wit B complex ( bagatelizowane przeze mnie) oraz kontrolne gastroskopie w celu zapobiegania rakowi żołądka ( dlatego 3 razy wykonałam)
Po 60 roku życia rozwinęły się u mnie objawy polineuropatii, w stopach symetrycznie powstał w części śródstopia niedowład, wynikający z ucisku na nerw w związku z płaskostopiem poprzecznym.
Były nieprzyjemne doznania mrowienia, zaburzenie odczuwania temperatury, określane jako parestezje, a przez nie zaburzenie zasypiania , stany depresyjne, niechęć do działania. Poziom wit B12 - 230 pg/ml, homocysteina 43,2 mol/l , p/ciała przeciwko komórkom okładzinowym 67,7. Lekarz rodzinny z wielkim trudem dał się namówić na wypisanie recepty na zastrzyki z wit. B12 , początkowo 100, po konsultacji hematologa 1000.
Po leczeniu witaminą B12 i. m. 1000 / co2 dni - 10 amp a póżniej 1 amp 1 raz / tydzień 1000 - kontrola wit B12 po 2 miesiącach -890 pg/ml homocysteina - 9mol/l , uległy poprawie wyniki lipidogramu, HDL wzrost, LDL spadek o ok. 30 % Ustąpiły parestezje, pozostał niedowład w części śródstopia, wrażliwość na ucisk części ciała, ale już nie tak nieprzyjemny, mniej nasilony.
Mój neurolog początkowo był bardzo sceptyczny co do mojej sugestii braku wit B12, niby później ją uznał, gdy zobaczył wynik ENG, które wykazało polineuropatię, ale nadal chce wykluczyć inne przyczyny w szpitalu, mam mieć badanie płynu mózgowo-rdzeniowego i całą diagnostykę. Piszę to wszystko tak szczegółowo, bo chcę przybliżyć od strony pacjenta tę sytuację, wiedząc, że to choroba rzadka i przez społeczeństwo a często samych lekarzy nieznana. Bardzo dziękuję za wspaniały wykład, wszystko to u mnie się potwierdziło, po raz pierwszy aż tak dokładnie mi ktoś to wytłumaczył . Wielkie dzięki z Polski!
And it’s important to note that the intrinsic factor test is only 40-60 percent accurate so as this amazing doctor has said you need to put all, the other factor s together . I had a level of 180 then 130 4 yrs later, before I was treated .My folate was 2 . All my M tests were high .. and I also have every symptom listed. I truly believe if I hadn’t started on daily b12 shots 18 months ago I would have died. Thank you so much to this amazing doctor who if you missed it very lightly also touched on the mylene sheath being affected by b12 deficiency decline in the sheath is also major factor in MS..
Yes!! Hundred 💯 hundred percent. Friend has been possibly misdiagnosed with MS (20% of MS pts are). B12 was in the dumps at 350pg
Amazing video this was such an in depth look at the topic, Thankyou
Thank you!
Impressive amount of info! Thank you!
Thank you so much. Is it possible for you to provide a link to the physiology diagram in the description at 11mins...? Fascinating learning this for the first time.
My Gps always thought I had a mild iron deficiency. I was deteriorating also due to a Candida overgrowth, robbing nutrients.
Sublingal B12 has improved my symptoms dramatically within 24hrs.
Cheers! Keep up the good work and sincere thanks for putting this up for us on RUclips 😊
Molly
Hi! I posted the link to the article in the description. Thank you for your comments.
@@gatesbrainhealth2639 Thank you 😊 wonderful info
What is the word at 10:00, “ A lot of discussion about…“ what? Thank you so much for this video!!🙏🏼❤️
"A lot of discussion about bismuth."
My son doesn't have IF, so he can't absorb B12. He has been diagnosed with pernicious anemia. We get him.B12 shots regularly methy and sometimes hydroxyl. Should he also be supplementing with B9, folate, or folic acid? I hear so much debate on all thing pernicious anemia. It gets confusing. It took years before finally getting a correct diagnosis. At first, they thought he had MS. This has been a long journey he's on, and it has taken its tole on him physically. He still struggles with his health quite a bit, but he is a lot better than he was 5 years ago. Can he absorb B9 without intrinsic factor? And is there a way to supplement with intrinsic factor 🤷♀️
Wow! Thank you I'll definitely check into this.
I received a B12 shot 2 days ago. I have been able to get caught up on my chores! Tears of joy! I still suffer from PPPD; but my fatigue is gone.
16:03 can you confirm what you said about the binding of B12
Dr. Ralph Green 👏👏👏
I have heard that low MMA can also be seen in B12 deficiency. What is your take on this?
I think h-pylori cause it in me. What if you test positive for IF but not positive partial cell antibodies?
Dr, do you work one on one with individuals? I would be interested. Thank you.
Hi, I do, my office’s email is info@gatesbrainhealth.com, and phone is (775) 507-2000.
Thanks
What would you conclude if one has pernicious anemia but has high serum levels of B12 ( without any supplements)?
Thank you
I'm wondering that as well. In my case, I've got high MCV confirmed by peripheral blood smear, positive IFA, high serum B12 (I've always taken an oral B-complex), and normal B9, MMA and homocysteine. Yet, I've experienced all the severe PA symptoms (neurologic included) and they're resolving very slowly with high dose injections of methylcobalamin. I've injected daily for 2 months now and am still making tiny improvements.
Intrinsic factor antibodies interfere with the B12 serum levels. A normal/high B12 can be seen with the IF antibodies. So you have to either test for IF antibodies or look at other areas of the blood which might indicate a B12 deficiency. I have elevated folate which apparently indicates a B12 deficiency (as you need B12 to process folate).
What if you homeo isn’t high but test positive for IF
Overlap between autoimmune gastritis & Hashimoto's thyroiditis. ?
Yes. PA is closely linked to Hashimotos, as is a B12 deficiency. Some people believe that it’s the B12 deficiency that causes Hashimotos which is interesting as I showed symptoms of anemia and then low stomach acid before I was diagnosed with Hashimotos. I’m trying to get my doctor to test me for PA at the moment and have been supplementing with a high b complex methylated supplement which has made me feel semi normal. Trying to get my gp to do anything is hard work so I might have to do a private test 😢
.